This RCT shows that CLD can be significantly improved with other interventions iovs.arvojournals.org/article.aspx?articleid=2695024

I also found very significant improvements in CLD as measured by CLDEQ-8, as used above, with punctal occlusion. Email adpconsultancy@gmail.com for further information. Results provided in Poster Session, BCLA, Liverpool 2017. The PDF can be found here www.eyedropsdatabase.co.uk/guest-article...-occlusion-treatment

As an update to previous postings on combating contact lens discomfort and patient drop-out here is the abstract from my recent clinical trial:

The Eye Doctor Premium® Heated Eye Compress Plus The Eye Doctor Tea Tree Oil Wipes
Trial
Authors: Andrew D. Price, FBDO(Hons)CL MBCLA, SW & C Jackson Opticians, 43-45
Welsh Row, Nantwich, CW5 5EW. Bill Long, BS, MBA, FAAO, Georgia, USA
Abstract
Purpose:
To determine if statistically significant differences (SSDs) can be measured using (1) the
Contact Lens Dry Eye Questionnaire (CLDEQ-, (2) the patient’s subjective vision score, (3)
the patient’s subjective comfort score (4) the Pre-Lens Non-Invasive Tear Breakup Time
(PLNITBUT), and (5) the Meiboscore among subjects who have mild or moderate later day
contact lens discomfort when treated with a warm heat application (The Eye Doctor Premium)
plus tea tree lid wipes (The Eye Doctor Tea Tree Lid Wipes) regimen.
Methods:
Potential subjects who met all inclusion and exclusion criteria were enrolled, instructed in the
use of the treatments, and dispensed with the treatments. Subjects were to return after 21 ± 2
days to complete the CLDEQ-8, subjective vision and comfort scoring, a clinical exam, and
exit the trial. Manufacturers’ instructions for application and use of the treatments were to be
followed and consultative services were to be used when needed. Additional clinical and
subjective data were collected at each visit.
Subjects were to continue with their habitual regimen of cleaning and disinfecting with their
normal products. Subjects were also to continue using any habitual contact lens rewetting
drops, eye drops, and/or dry eye oral supplements. Contact lenses and associated cleaning and
eyecare products were not provided to subjects in this trial.
Subjects received clinical exams and provided subjective assessments at the Baseline Visit.
They were instructed in using the Eye Doctor Premium® Heated Eye Compress and Tea Tree
Oil Eyelid Wipes, treated, and dispensed to use them for 21 ± 2 days at which time they were
to return for a clinical exam, subjective assessments, and to exit the trial.
Results:
For the primary variables, statistically significant improvements were found for 75% of
symptoms queried with the CLDEQ-8 with improvements that may be subjectively and
clinically significant for all symptoms. Subjective vision and overall lens comfort scores were
improved with statistically significant improvement found for subjective near vision. No
statistically significant improvement was found for the meiboscore.
For additional variables, 75% of subjects were indicated to be enthusiastic promoters of the
treatment. Small improvements were found for some clinical vision measures, daily wearing
time, PLNITBUT, and biomicroscopy. Seven (70%) of completing subjects gave favorable
comments about the treatment.
Conclusion:
These results indicate that treatment with The Eye Doctor Premium® Heated Eye Compress
Plus The Eye Doctor Tea Tree Oil Wipes produces statistically significant improvements in
many contact lens symptoms among soft contact lens wearers that may not be reflected in a
categorical clinical test and that the treatment may be enthusiastically recommended by
patients. These results indicate that The Eye Doctor Premium® Heated Eye Compress Plus
The Eye Doctor Tea Tree Oil Wipes is a promising treatment for soft contact lens wearers
who have complaints, enabling them to wear lenses longer and with fewer problems, and so
may be thought to aid contact lens patient retention and reduce drop-out.
Andrew D. Price, FBDO(Hons)CL MBCLA, SW & C Jackson Opticians, 43-45 Welsh Row,
Nantwich, CW5 5EW. Bill Long, BS, MBA, FAAO, Georgia, USA. All rights reserved

The relevant PDF can be found here www.eyedropsdatabase.co.uk/guest-article...ntact-lens-symptopms